A two-component therapy for adults with late-onset Pompe disease (LOPD) weighing 88 lbs or more who are not improving on their current enzyme replacement therapy (ERT).

POMBILITI + OPFOLDA treatment every 2 weeks

JARED
DIAGNOSED WITH LOPD IN 1998

How to switch from another treatment

If you and your doctor have decided to switch to POMBILITI + OPFOLDA, you can start POMBILITI + OPFOLDA on your next scheduled treatment day (2 weeks after your last ERT dose).

Treatment day at a glance

Like other LOPD treatments, POMBILITI + OPFOLDA therapy is given every 2 weeks. For OPFOLDA to become optimally absorbed and functional inside your bloodstream, it must be taken while you are fasting.

POMBILITI must be taken in combination with OPFOLDA. Because POMBILITI + OPFOLDA were designed to work exclusively with each other, they must be taken at the right time under the right circumstances. Neither should be taken with another Pompe treatment.

The typical treatment day should look like this:

POMBILITI + OPFOLDA dosing is determined by your actual body weight. You will take 3 or 4 OPFOLDA capsules depending on your weight.* Your doctor may recommend taking medicine such as an antihistamine, antipyretic (fever reducer), or corticosteroid before your POMBILITI infusion, especially if you took a medication with your previous ERT. Always take your medication exactly as directed by your healthcare provider.

*Talk to your doctor if you have kidney problems because your OPFOLDA dose may be different.

2 hours before taking OPFOLDA:

Avoid all food and most beverages, to ensure OPFOLDA will be able to bind to POMBILITI in your bloodstream
It’s okay to drink certain fluids throughout your treatment day
You may have unsweetened beverages such as water, tea, or coffee with no cream, sugar, or sweeteners

1 hour before your POMBILITI infusion:

Take OPFOLDA exactly as directed by your healthcare provider
Swallow OPFOLDA capsules whole only with unsweetened beverages, including water, tea, or coffee with no cream, sugar, or sweeteners